Therapeutic immunization and local low-dose tumor irradiation, a reinforcing combination

Reply to “Letter to the Editor: ‘Low-dose whole body irradiation: a potential therapeutic modality’”

In their letter (17), Chander M. Pathak and Krishan K. Khanduja commended the findings of our paper (27). We are grateful to them for highlighting the clinical relevance and important implications of our research. However, two issues require clarification. First, we did not simultaneously investigate the temporal long-term impact of whole body low-dose radiation (WBLDR) on both pancreatic and r...

Letter to the editor: Low-dose whole body irradiation: a potential therapeutic modality?

TO THE EDITOR: The recent article published by Zhang et al. (11) in this Journal is indeed very interesting and has great clinical relevance with far-reaching consequences. This appears to be the first detailed report that suggests that multiple exposures to whole body low-dose radiation (WB-LDR) significantly suppresses diabetes-induced systemic and renal inflammatory response and renal oxidat...

Combination immunotherapy with oncolytic vaccinia virus and checkpoint inhibitor following local tumor irradiation

Oncolytic virotherapy is safe and clinically active in solid tumors, however its efficacy in hematologic malignancies as well as in combination with checkpoint inhibitors and radiation is unexplored. To simulate advanced lymphoma, A20 cells were injected subcutaneously on bilateral flanks of BALB/c mice and treatment initiated on day 17 to only the right flank tumor with local irradiation (Irr)...

Low dose hypersensitivity after high-LET irradiation

An unexpected hypersensitivity has been reported for several cell lines at low doses (<1Gy), which is not consistent with the linear-quadratic approach currently used in general for the description of survival curves [1,2,3,4]. The corresponding substructure of the survival curves has been attributed to induced radioresistance. There are indications, that high-LET irradiation with neutron or pi...

Low-dose Gemcitabine and Carboplatin as a Good Palliation for Local Symptoms in Advanced Transitional Cell Carcinoma of Bladder